Deborah, I've got a .45 Kimber. Custom scrimshaw handle. Beautiful piece.
Brenda, you can also start off with a .22, which tends to be more for target practice, or a little .25 Beretta, which is a nice "ladies" gun. Not an insult, just easier fit in a woman's hand. Not a lot of kick, or punch - so keep that in mind if you're looking to stop big game. But it's small enough to fit in a purse, which makes it an easy carry piece.